Woman with facial diagram showing thread lifting target areas for non-surgical facial rejuvenation at One8Clinic in Sandton

The Power Duo: Fillers + Wrinkle Relaxing Injections for Natural Facial Rejuvenation

April 01, 20254 min read

When it comes to non-surgical facial rejuvenation, combining dermal fillers with wrinkle-relaxing injections is increasingly seen as the most effective way to restore youthful contours and smooth skin—without altering your natural appearance.

At One8Clinic, located in Melrose Arch, Sandton, this advanced approach is personalised for each client, ensuring subtle, refined, and natural-looking results.

Related: Fillers vs. Botulinum Toxin Injections — Which Is Right for You?

oung woman with facial contouring lines illustrating targeted areas for non-surgical facial rejuvenation at One8Clinic, Melrose Arch, Johannesburg.

What Are Dermal Fillers and Wrinkle Relaxing Injections?

Understanding Two of the Most Popular Non-Surgical Anti-Ageing Treatments

At One8Clinic, we use only SAHPRA-approved products to ensure clinical-grade safety and results.

  • Dermal fillers are hyaluronic acid-based injectables that restore lost volume, sculpt facial contours, and soften static lines. Common areas treated include the cheeks, lips, nasolabial folds, and under-eyes.

  • Wrinkle-relaxing injections use botulinum toxin to gently relax the facial muscles that cause dynamic wrinkles—such as crow’s feet, frown lines, and forehead creases.

Together, they offer a complementary approach to treating both the volume loss and expression lines that appear with age.

Why Combine Dermal Fillers with Wrinkle Injections?

The Science Behind Dual-Action Facial Rejuvenation

Used together, these treatments deliver comprehensive, balanced results:

  • Fillers restore volume and definition

  • Wrinkle relaxers reduce dynamic facial movement and soften expression lines

“The combined use of botulinum toxin and fillers can restore facial appearance by the dual mechanisms of reflation and relaxation.”
— Journal of Drugs in Dermatology

This approach treats the root causes of facial ageing while preserving your natural expressions.

Split image showing before and after results of non-surgical facial rejuvenation — smoother skin and lifted features at One8Clinic in Sandton, Johannesburg.

Top Benefits of Combining Fillers and Wrinkle-Relaxing Injections

  • Comprehensive rejuvenation: Targets multiple ageing concerns in one tailored plan

  • Extended longevity: Reduced muscle movement slows filler breakdown

  • Natural-looking results: Balanced proportions and smoother skin without a “frozen” look

  • Minimally invasive: No downtime, no anaesthesia, no incisions

  • Highly customisable: Tailored to your unique facial structure and goals

“The combination of botulinum toxin and fillers is versatile and bespoke to every individual. Together, they are a powerhouse for facial rejuvenation.”
— Dr. Mauricio de Maio, International Aesthetic Expert

What Experts Say: Is This Combination Backed by Science?

Yes—numerous studies support the enhanced results achieved when these treatments are used together.

  • When wrinkle relaxing injections are used first, it reduces facial movement that could otherwise cause dermal filler to degrade faster, helping to prolong the effects.

  • A 2021 review in JDD found that patient satisfaction was highest in combination treatments versus fillers or toxins alone.

Clinics worldwide—like One8Clinic—favour this approach for its safety, versatility, and consistently high client satisfaction.

Why Choose One8Clinic for Combined Facial Rejuvenation?

Woman receiving professional non-surgical facial rejuvenation treatment at One8Clinic, Sandton — enhancing skin glow and hydration with expert medical care.

Located in Melrose Arch, One8Clinic offers a tranquil, luxury environment where expert-led care is standard.

Here’s what makes us different:

  • Personalised consultations with highly trained aesthetic medical practitioners

  • Only SAHPRA-approved injectables

  • A bespoke treatment plan based on facial analysis, not a one-size-fits-all approach

  • Natural, elegant outcomes—no overfilled or frozen effects

  • A supportive, wellness-driven setting prioritising your comfort and confidence

What to Expect: Your One8Clinic Treatment Journey

Here’s a step-by-step overview of your experience:

1. Personalised Consultation

A comprehensive facial assessment is performed to determine the best treatment plan based on your anatomy, skin quality, and aesthetic goals.

2. In-Clinic Procedure

  • Injections are quick, targeted, and performed with precision

  • Topical numbing is applied for comfort

  • Sessions typically last 30–60 minutes

3. Recovery and Results

  • Mild swelling, redness, or tenderness may occur, typically resolving within hours to a few days

  • Avoid strenuous exercise, alcohol, makeup, and exposure to heat for at least 24 hours to minimise swelling and bruising

  • Dermal fillers provide immediate volume and contouring, while wrinkle relaxing injections take 3–7 days to take effect, with peak results visible around day 10–14

You’ll receive a full set of aftercare instructions, and our support team is always available to guide your post-treatment experience.

Before and after image of a woman showing smoother skin and enhanced facial symmetry — non-surgical facial rejuvenation results

Are These Treatments Safe? What You Should Know

Yes—when performed by experienced professionals in a clinical setting, these treatments are safe and well-tolerated.

Potential side effects (usually mild and temporary) include:

  • Redness or tenderness at injection sites

  • Minor bruising or swelling

At One8Clinic, we uphold the highest standards of medical care to ensure your safety and peace of mind.

Ready to Smooth, Lift, and Refresh—Naturally?

Combining dermal fillers and wrinkle relaxing injections is one of the most effective, non-surgical ways to rejuvenate your appearance and restore youthful volume and balance—without looking overdone.

📍 Book your personalised consultation at One8Clinic, located in Melrose Arch, Sandton
Let’s create a treatment plan that helps you look as vibrant and refreshed as you feel.

One8Clinic, in the heart of Melrose Arch, provides comprehensive medical care and a wide range of aesthetic services and procedures.

One8Clinic

One8Clinic, in the heart of Melrose Arch, provides comprehensive medical care and a wide range of aesthetic services and procedures.

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